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Ecdysterone bodybuilding benefits
Posted by Fred
I've beeing using your Ecdybolin Supplement and it's giving me great results in muscle gains and fat loss, thanks! I just wanted to share this article on ecdysterone benefits from the Muscle
and Fitness April 1997 issue.
Can The Plant Sterol
Ecdysterone Help Your muscles Grow?
By Rick Brunner
plant sterols – a group of compounds characterized by their chemical structure
– have certain similarities to anabolic steroids, an important question bears
answering: Are plant sterols anabolic in humans? This is something that has
puzzled sports researchers for years. And if scientists still can’t agree
whether plant sterols help promote protein synthesis in human muscle cells,
then athletes are even more confused. Though similar in structure to anabolic
steroids (chemically speaking), most of the plant sterols used by athletes over
the past decade, like sitosterols and stigmasterols, have no effect on
stimulating protein synthesis.
think we have not only been using the wrong plant sterols but have tossed all
plant sterols into the same pot. That’s like putting glutamine into the same
class as other amino acids such as threonine (while significant research backs
up glutamine’s use in sport nutrition as a cell volumizer and immune
stimulator, threonine plays a limited role). I believe that some plant sterols,
but by no means all of them, help support muscle growth in bodybuilders who
consume an optimal diet rich in protein.
1988, I’ve worked closely with leading experts in plant sterol research as well
as coaches and athletes who have used plant sterols. The two main sterols used
worldwide are an ecdysterone called 20-hydroxyecdysterone and the furostanols. In my opinion, these plant sterols can be
anabolic in human muscle cells and are of great use to athletes. The plant
sterol 20-hydroxyecdysterone – also known as ecdysterone or beta-ecdysterone –
has received more attention, both in research since 1966 and use by athletes
training programs of bodybuilders and other strength athletes may benefit from
20-hydroxyecdysterone’s growth-promoting effects during high-volume and
high-intensity training cycles. “With ecdysterone, I can train within a greater
intensity zone and higher tonnage without overtraining, and I make greater
gains than I thought possible,” says Mike “Bubba” Stokes, two time (1995-96)
Armed Forces powerlifting champion (1,870 pounds total at a 198-pound
bodyweight). “In the past, I’d kill myself if I tried to increase my volume at
a high weight, but the plant sterols allows me to safely train heavy, with
almost twice the volume.”
RESEARCH: EAST VS. WEST
Why do some
researchers believe 20-hydroxyecdysterone is anabolic in humans, while others
have their doubts? Perhaps it comes down to having the research on which to
base their decision. Scientists and athletes alike deserve proof. The
scientific research conducted with ecdysterones on animals and humans has been
done outside the United States in countries like Japan, Uzbekistan, Bulgaria,
the Ukraine, Russia and France. This research is often published by “outsiders”
in foreign journals in a foreign language. Unless a researcher in the West
really digs, the study gets buried along with the thousands of others produced
every year. The research simply falls through the cracks.
addition, some researchers question the validity of the animal studies – are
they valid for humans? Pioneering research conducted by Vladimir Syrov, PhD,
from Tashkent, Uzbekistan, Julia Holadova, PhD, from Kiev in the Ukraine, and
others from the former Eastern Bloc have confirmed that
20-hydroxyecdysteroneincreasess lean body mass, hemoglobin and erythrocyte
(cells transport oxygen) content in animals and humans. (1-7); According to
Syrov, scientists from Russia, and other former Eastern Bloc countries tested
20-hydroxyecdysterone on elite athletes from many sports. “Ecdysterone
increases the capacity for work, improves recovery and stimulates muscle growth
in well-trained athletes,” he explains.
Schroeder, consulting strength coach to Olympic and professional level
athletes, has recommended 20-hydroxyecdysterone to lifters for the past five
years. “In intense training ecdysterone has no substitute,” he says “It has
allowed the athletes I train and myself to reach championship levels that were
impossible to reach before, drug-free.”
proponent of plant sterol use is Dragomir Cioroslan, head coach of the U.S.
Olympic weightlifting team. “In elite weightlifting, a supplement either works
or it doesn’t. Because of the
seriousness of our training, there’s no room for placebo effect. Ecdysterone
has helped elevate our performance and stay competitive.”
United States and other western countries, research on ecdysterone has taken a
different path than in the former Eastern Bloc countries. Particularly in the
United States, the interest targets the effect of ecdysterone on insect
early days of ecdysterone research on animals, Japanese scientists Okui, Otaka
and Matsuda discovered during the 1960’s that ecdysterones significantly
increased the lean bodyweight and bone density of birds and rodents. This
included an increase in the intensity of the biosynthesis of proteins in liver,
heart, kidney and muscle.” (8)
By the late
1970’s, Syrov and other former Eastern Bloc researchers quickly recognized the
tremendous anabolic activity of ecdysterones from plants. So did Sergey
Portougalov, MM, PhD, director of the Laboratory of Biologically Active
Substances in Moscow, who recommended that the Soviet Olympic Committee
dispense it to elite U.S.S.R. athletes of Olympic and world-class caliber.
Today, the Russian supplement which contains the plant steroid
20-hydroxyecdysterone, is used in the strength-training programs of many elite
plants have been discovered to contain a significant quantity of
ecdysterone. Using ethanol as an
extraction solvent, I’ve isolated 20-hydroxyecdysterone from the African Ajuga remota, the Pfaffia paniculata root from Brazil and a specific variety of Spinacia oleracea grown in California.
All three plants have been eaten by humans for many years and are widely known
folk medicine to contain tonic and adaptogenic (enhancing the body’s ability to
adapt to stress) effects.
ecdysterone work in human muscle? According to researchers from Japan, Russia,
Uzbekistan, and the Ukraine, 20-hydroxyecdysterone has a pronounced capacity to
stimulate muscle cell cytoplasm by increasing the assembly of protein chains
from amino acids. (2) along with strength training, 20-hydroxyecdysterone has been
shown to increase protein synthesis by 190% (±31) above that of control
animals, while training alone caused an increase of 131% (±20.3).
for the pronounced increase in muscle protein synthesis has been traced to the
action of ecdysterone in the muscle cell during the translation and
translocation processes of protein growth.(3) Syrov’s studies since 1976 have
shown ecdysterone to stimulate a wider spectrum of anabolic action on
contractile proteins of skeletal muscle and a pronounced influence on
increasing physical endurance. Holadova has hypothesized that the anabolic
action of 20-hydroxyecdysterone is in part due to an increase in potassium and
calcium ion levels within the cell that cause it to swell, leading to an
increase in DNA,RNA and protein synthesis.
is not only safe but healthy. Research has shown that 20-hydroxyecdysterone
helps stabilize cells from potential damage by cortisol, normalize the cells’
adenosine triphosphate and creatine energetic processes, increase the adaptive
potential of the heart and improve liver
function. (1,4-7) Plus,
unlike anabolic steroids that reduce the body’s ability to make testosterone,
ecdysterone has no such harmful effect – it works with the body’s natural
testosterone and growth hormone to increase muscle protein growth. (1)
dosage for athletes using 20-hydroxyecdysterone is usually 300 mg but can be as
high as 900mg. Plant extracts containing 20-hydroxyecdysterone are now
available in the United States. If you use 20-hydroxyecdysterone take it with
creatine, glutamine and a high-protein diet for maximum benefit. A large amount
of amino acids in the cell, along with the increase in cell volume, may allow
20-hydroxyecdysterone to stimulate the assembly of additional amino acids into
muscle proteins. In this way, you may be able to stimulate greater gains in
muscle mass and strength than you’ve ever achieved before.
Phytoecdysteroids: their biological effects in the body of higher animals and
the outlook for their use in medicine. Experimental and Clinical Pharmacology
57(5): 61 - 66, 1994.
., et al. The action of methandrostenolone and ecdysterone on the physical
endurance of animals and on protein metabolism in the skeletal muscle.
Pharmacology and Toxicology 51(6): 57 – 60, 1988.
Mechanism of the anabolic action of phytoecdysteroids in mammals. Biological
Science 11: 16 – 20, 1984.
et al. Effect of phytoecdysteroids and nerobol on parameters of
carbohydrate and lipid metabolism and phospholipid spectrum of liver
mitochondrial membrane in experimental diabetes mellitus of rats. Ukrainian
Biochemical Journal 64(4): 61 – 67, 1992.
Ermishina, O.A. The effect of ecdysterone on experimental arrhythmias and
changes in the hemodynamics and myocardial contractility induced by coronary
artery occlusion. Pharmacology and
Toxicology 54(1): 27 – 29, 1991.
Khushbaktova, Z.A., Nabiev, A.N. An experimental study of the hepatoprotective
properties of phytoecdysteroids and nerobol in carbon tetrachloride-induced
liver lesion. Experimental and Clinical Pharmacology 55(3): 61 – 65, 1992.
Saad, L.M., Kholodova, Y.D. Antiradical properties and antioxidant activity of
ecdysterone. Ukrainian Biochemical Journal 64(1): 114 – 117, 1992.
Okui, S., et al.
Stimulation of protein synthesis in mouse liver by insect-moulting steroids. Chemical
and Pharmaceutical Bulletin (Tokyo) 16(2):384 – 387, 1968.
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The information presented is intended to be used for educational purposes only. The statements made have not been evaluated by the Food and Drug Administration (U.S.). This product is not intended to diagnose, treat, cure or prevent any condition or disease. Please consult with your own physician or health care practitioner regarding any suggestions and recommendations made.